Aspirin damage in the rat kidney in the intact animal and after unilateral nephrectomy

J Pathol. 1976 Sep;120(1):43-8. doi: 10.1002/path.1711200106.


Aspirin caused epithelial hyperplasia, papillary necrosis with calcification and cortical changes in the rat kidney. After unilateral nephrectomy the lesions appeared more rapidly and were more severe. In the electron microscope the earliest changes were observed in the interstitial cells.

MeSH terms

  • Animals
  • Aspirin / toxicity*
  • Connective Tissue / ultrastructure
  • Connective Tissue Cells
  • Epithelial Cells
  • Epithelium / ultrastructure
  • Female
  • Kidney / ultrastructure
  • Kidney Diseases / chemically induced*
  • Kidney Diseases / pathology
  • Kidney Papillary Necrosis / chemically induced*
  • Kidney Papillary Necrosis / pathology
  • Nephrectomy
  • Rats
  • Time Factors


  • Aspirin