Size of pancreas in children and adolescents with type I (insulin-dependent) diabetes

J Clin Ultrasound. 1998 Oct;26(8):391-5. doi: 10.1002/(sici)1097-0096(199810)26:8<391::aid-jcu3>;2-d.


Purpose: The aim of this study was to evaluate the influence of insulin-dependent diabetes mellitus (IDDM) on the size of the pancreas in children.

Methods: Pancreas size was evaluated sonographically in a group of 60 diabetic children and adolescents, aged 3-15 years, and 60 sex- and age-matched healthy controls.

Results: A significant reduction in pancreatic area and other parameters was found in diabetic patients particularly in children aged 8-12 and 13-15 years. The pancreas was larger in children 3-7 years old who had had IDDM for 2 years of less (mean size, 8.61 cm2) than in children 8-12 and 13-15 years old who had had IDDM for more than 5 years (mean size, 8.06 and 8.40 cm2, respectively). An inverse correlation between area of the pancreas and duration of IDDM was seen in all age groups (p < 0.05).

Conclusions: Diabetes affects the growth of the pancreas in children with IDDM. Sonography can be used to noninvasively evaluate the influence of the disease on pancreas size.

MeSH terms

  • Adolescent
  • Analysis of Variance
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Diabetes Mellitus, Type 1 / pathology*
  • Female
  • Humans
  • Infant
  • Male
  • Pancreas / diagnostic imaging
  • Pancreas / pathology*
  • Reproducibility of Results
  • Statistics, Nonparametric
  • Ultrasonography