Cobalamin deficiency presenting with cutaneous hyperpigmentation: a report of two siblings

Pediatr Hematol Oncol. 1998 Sep-Oct;15(5):447-50. doi: 10.3109/08880019809016575.


The authors report on 2 children with pernicious anemia, sisters, who presented with hypermelanosis as one of the clinical manifestations. The hypermelanosis disappeared with adequate treatment of vitamin B12 deficiency. Vitamin B12 deficiency should be considered in the differential diagnosis of a child presenting with hyperpigmentation and macrocytic red cell indices.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Diagnosis, Differential
  • Female
  • Humans
  • Hyperpigmentation / etiology*
  • Hyperpigmentation / metabolism
  • Melanins / metabolism*
  • Vitamin B 12 Deficiency / complications
  • Vitamin B 12 Deficiency / diagnosis*
  • Vitamin B 12 Deficiency / metabolism


  • Melanins