Revealing some oncofetal antigens in peripheral blood mononuclear cells of donors and patients with B-chronic lymphocytic leukemia

Leuk Res. 1998 Nov;22(11):1009-13. doi: 10.1016/s0145-2126(98)00123-4.

Abstract

Eidelman et al. showed that the expression of functional carcinoembryonic antigen (CEA) on the surface of cells can block terminal differentiation and maintain their proliferative capabilities. This led us to analyze the expression of CEA, trophoblast-specific beta-1-glycoprotein (TSG) and embryonic prealbumin-1 (EPA) in peripheral blood mononuclear cells (PBMs) isolated from healthy donors and patients with B-chronic lymphocytic leukemia (B-CLL). We demonstrated that the PBMs of patients with B-CLL differed from PBMs of healthy donors by having greater numbers of CEA-, EPA- and TSG-positive cells.

MeSH terms

  • Antigens, Neoplasm / blood*
  • Blood Donors
  • Carcinoembryonic Antigen / blood
  • Flow Cytometry
  • Glycoproteins / blood*
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / immunology*
  • Leukocytes, Mononuclear / immunology*
  • Prealbumin
  • Pregnancy-Specific beta 1-Glycoproteins / analysis

Substances

  • Antigens, Neoplasm
  • Carcinoembryonic Antigen
  • Glycoproteins
  • Prealbumin
  • Pregnancy-Specific beta 1-Glycoproteins
  • embryonic prealbumin
  • oncofetal antigens