A Specific T-cell Subset With CD4+/CD38- Markers Derived From HIV-1 Carriers Induces Apoptosis in Healthy Donor-Derived T-lymphocytes

Virus Res. 1998 Jul;56(1):115-22. doi: 10.1016/s0168-1702(98)00052-5.

Abstract

Apoptosis is an important mechanism of human immunodeficiency virus type 1 (HIV-1)-induced T-cell depletion. Our recent findings revealed mitogenic stimulation-dependent apoptosis induction in healthy donor-derived peripheral blood T-lymphocytes after adsorption with defective HIV-1 particles through acquirement by a subset of CD4+/CD38- cells of specific killer function. Based on these in vitro observations, we have extended the significance of this killing activity of CD4+/CD38- cells directly derived from HIV-1 carriers. The CD4+/CD38- cells from HIV-1-positive individuals showed significantly higher cell-killing activities than those from HIV-1-negative donors by co-culture with allogeneic resting T-cells after mitogenic stimulation. Furthermore, most of the samples induced apoptosis in a Fas-dependent manner. Thus, it is suggested that HIV-1 infection-related apoptosis is triggered by inappropriate activation of a certain resting T-cell subset, presumably due to adsorption with HIV-1 particles.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / immunology
  • Antibodies, Monoclonal
  • Apoptosis / immunology*
  • Biomarkers
  • CD4-Positive T-Lymphocytes / immunology*
  • Cells, Cultured
  • HIV Seronegativity
  • HIV Seropositivity
  • HIV-1 / immunology*
  • Humans
  • Lymphocyte Activation
  • T-Lymphocyte Subsets / immunology*
  • fas Receptor / immunology

Substances

  • Antibodies, Monoclonal
  • Biomarkers
  • fas Receptor