Nicotine availability from Eclipse tobacco-heating cigarette

Psychopharmacology (Berl). 1998 Oct;139(3):288-90. doi: 10.1007/s002130050719.


A cigarette which heats rather than burns tobacco (Premier) was introduced in 1988, but was unacceptable due to unpleasant taste and low nicotine intake. We examined availability of nicotine from a new version (Eclipse), in the same four subjects as our earlier Premier study. Average blood nicotine boosts of 23.7 and 17.8 ng/ml were obtained from smoking a first and second Eclipse. This substantially exceeds intake from Premier (boost 13 ng/ml) and that obtained by heavy smokers from conventional brands (boost 12-15 ng/ml). Eclipse (or similar product) may be the best option for averting Peto's dire warnings of rising millions of annual smoking deaths in the 2020s, and its potential for large-scale, long-term switching warrants further study.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Dizziness / chemically induced
  • Evaluation Studies as Topic
  • Heart Rate / drug effects
  • Humans
  • Male
  • Nicotine / blood*
  • Nicotine / pharmacology
  • Nicotinic Agonists / blood*
  • Nicotinic Agonists / pharmacology
  • Smoking* / adverse effects


  • Nicotinic Agonists
  • Nicotine