Developmental expression of the cell adhesion molecule-like protein tyrosine phosphatases LAR, RPTPdelta and RPTPsigma in the mouse

Mech Dev. 1998 Sep;77(1):59-62. doi: 10.1016/s0925-4773(98)00119-1.

Abstract

Using RNA in situ hybridization we compared the expression patterns of the cell adhesion molecule-like receptor-type protein tyrosine phosphatases LAR, RPTP sigma and RPTP sigma during mouse development. We found that LAR is expressed in basal lamina-associated epithelial tissues of (neuro)ectodermal, neural crest/ectomesenchyme and endodermal origin. RPTP sigma is found in (neuro)ectodermal, neural crest-derived systems and in mesoderm-derived tissues. The expression pattern of RPTP sigma largely parallels that of RPTP sigma, in concordance with their proposed evolutionary history

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Adhesion Molecules / genetics*
  • Embryo, Mammalian / metabolism
  • Embryonic and Fetal Development / genetics*
  • Female
  • Fetus / metabolism
  • Gene Expression Regulation, Developmental
  • In Situ Hybridization
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred Strains
  • Nerve Tissue Proteins / genetics
  • Protein Tyrosine Phosphatases / genetics*
  • RNA / genetics
  • RNA / metabolism
  • Receptor-Like Protein Tyrosine Phosphatases, Class 2
  • Receptor-Like Protein Tyrosine Phosphatases, Class 4
  • Receptor-Like Protein Tyrosine Phosphatases, Class 5
  • Receptors, Cell Surface*
  • Tissue Distribution

Substances

  • Cell Adhesion Molecules
  • Nerve Tissue Proteins
  • Receptors, Cell Surface
  • RNA
  • Protein Tyrosine Phosphatases
  • Ptpra protein, mouse
  • Ptprg protein, mouse
  • Ptprs protein, mouse
  • Receptor-Like Protein Tyrosine Phosphatases, Class 2
  • Receptor-Like Protein Tyrosine Phosphatases, Class 4
  • Receptor-Like Protein Tyrosine Phosphatases, Class 5