Changes in indices for the principle metabolic pathways of bodily adaptation in gestoses were studied as were potentialities of correction thereof with ozonohemotherapy. Revealed in particular was an indirect influence of OHT on glycolysis and gluconeogenesis together with a stimulatory action on the activity of the key enzyme of the pentosephosphatic pathway. Disturbances in the course of processes of glycolysis and gluconeogenesis in the organism of the gestoses patients warrant further study to work out options for a specific correction of intracellular metabolism in the given pathology and to prevent complications.