Congenital syphilis after treatment of maternal syphilis with a penicillin regimen exceeding CDC guidelines

Infect Dis Obstet Gynecol. 1998;6(3):134-7. doi: 10.1002/(SICI)1098-0997(1998)6:3<134::AID-IDOG7>3.0.CO;2-X.


Background: Although congenital syphilis usually occurs as a result of a failure to detect and treat syphilis in pregnant women, failures of the currently recommended regimen to prevent congenital syphilis have been reported.

Case: This report describes an infant with congenital syphilis despite maternal treatment with a regimen exceeding current CDC guidelines.

Conclusion: Regardless of the regimen used to treat syphilis during pregnancy, clinicians should recognize the possibility of occasional treatment failures and the importance of adequate follow-up of infants at risk for congenital syphilis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / administration & dosage*
  • Centers for Disease Control and Prevention, U.S.
  • Diagnosis, Differential
  • Female
  • Humans
  • Infant, Newborn
  • Penicillins / administration & dosage*
  • Practice Guidelines as Topic
  • Pregnancy
  • Pregnancy Complications, Infectious / drug therapy*
  • Syphilis, Congenital / diagnosis*
  • Syphilis, Congenital / etiology*
  • Syphilis, Latent / complications
  • Syphilis, Latent / drug therapy*
  • Treatment Failure
  • United States


  • Anti-Bacterial Agents
  • Penicillins