Interleukin-1

Int J Biochem Cell Biol. 1998 Oct;30(10):1075-9. doi: 10.1016/s1357-2725(98)00081-8.

Abstract

Interleukin 1 (IL1) is a primary regulator of inflammatory and immune responses. Via its type I receptor it activates specific protein kinases, including the NF kappa B inducing kinase (NIK) and three distinct mitogen-activated protein (MAP) kinase cascades. These modulate a number of transcription factors including NF kappa B, AP1 and CREB each of which regulate a plethora of immediate early genes central to the inflammatory response. Phase I clinical trials of the soluble type I receptor and IRAP indicate that these have potential anti-inflammatory effects.

Publication types

  • Review

MeSH terms

  • Adaptor Protein Complex 1
  • Adaptor Protein Complex alpha Subunits
  • Adaptor Proteins, Vesicular Transport
  • Animals
  • CREB-Binding Protein
  • Calcium-Calmodulin-Dependent Protein Kinases / biosynthesis*
  • Enzyme Induction
  • Genes, Immediate-Early
  • Inflammation / drug therapy
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1 / physiology*
  • Membrane Proteins / biosynthesis
  • NF-kappa B / biosynthesis*
  • Nuclear Proteins / biosynthesis
  • Receptors, Interleukin-1 / antagonists & inhibitors
  • Receptors, Interleukin-1 / physiology*
  • Recombinant Proteins / therapeutic use
  • Sialoglycoproteins / therapeutic use
  • Trans-Activators / biosynthesis

Substances

  • Adaptor Protein Complex 1
  • Adaptor Protein Complex alpha Subunits
  • Adaptor Proteins, Vesicular Transport
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1
  • Membrane Proteins
  • NF-kappa B
  • Nuclear Proteins
  • Receptors, Interleukin-1
  • Recombinant Proteins
  • Sialoglycoproteins
  • Trans-Activators
  • CREB-Binding Protein
  • Calcium-Calmodulin-Dependent Protein Kinases