An ultrastructural study of the phagocytosis of Burkholderia pseudomallei

Microbios. 1998;94(377):35-45.


Burkholderia pseudomallei causes melioidosis and is believed to be an intracellular pathogen in human and animal disease. The uptake of B. pseudomallei by mouse peritoneal macrophages and cells in tissue culture was examined by electron microscopy. In all the systems studied B. pseudomallei were phagocytosed and apparently inhibited the normal processes of intracellular killing. Destruction of the phagosome membrane occurred and the bacteria escaped into the cytoplasm.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Burkholderia pseudomallei / immunology*
  • Burkholderia pseudomallei / physiology
  • Burkholderia pseudomallei / ultrastructure
  • Cell Line
  • HeLa Cells
  • Humans
  • Lysosomes / immunology
  • Macrophages, Peritoneal / immunology
  • Melioidosis / immunology*
  • Mice
  • Microscopy, Electron
  • Phagocytosis / physiology*
  • Phagosomes / immunology
  • Thailand
  • U937 Cells