The evolution of self-tolerance: a new cell arises to meet the challenge of self-reactivity

Immunol Today. 1998 Oct;19(10):448-54. doi: 10.1016/s0167-5699(98)01328-0.


Naive T cells can become either tolerant or immune as a result of their first encounter with antigen. It has been suggested that lymphoid and myeloid dendritic cells, respectively, control such decisions. Here, Barbara Fazekas de St Groth discusses evolutionary aspects of the functional distinction between these two types of dendritic cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigen Presentation / immunology
  • Autoimmune Diseases / immunology
  • Dendritic Cells / classification
  • Dendritic Cells / immunology*
  • Humans
  • Immunity, Cellular
  • Lymphoid Tissue / cytology
  • Lymphoid Tissue / immunology*
  • Mice
  • Phylogeny
  • Self Tolerance / immunology*
  • T-Lymphocytes / immunology