T-cell anergy and altered T-cell receptor signaling: effects on autoimmune disease

Immunol Today. 1998 Oct;19(10):468-73. doi: 10.1016/s0167-5699(98)01326-7.

Abstract

Immunological self-tolerance can be acquired by several mechanisms, including the induction of anergy in autoreactive T cells. In this sense, anergy is predictably advantageous for the immune system. Here, Konstantin Salojin and colleagues present an alternative view that the induction of anergy in regulatory T cells may be harmful to the host and elicit autoimmune disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology*
  • Clonal Anergy / immunology*
  • Humans
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred NOD
  • Receptors, Antigen, T-Cell / immunology*
  • T-Lymphocytes / immunology*

Substances

  • Receptors, Antigen, T-Cell