[Relief of neuropathic pain with intravenous magnesium]

Masui. 1998 Sep;47(9):1109-13.
[Article in Japanese]


We investigated the effect of intravenous magnesium, a N-methyl-D-asparate (NMDA) receptor antagonist, in 8 patients suffering from neuropathic pain (post herpetic neuralgia or causalgia etc.). After the nerve block, magnesium sulphate (0.5 mol.l-1) 5 ml was administered intravenously by bolus infusion taking 5 min, followed by continuous infusion of the same dose for one hour. All patients were treated with this therapy once a week. In 4 patients, VAS score decreased 3 points or more when this therapy had been administered 3 to 11 times. In 2 patients, VAS score did not change, and the analgesic effect of magnesium was not certain in other 2 patients. Some patients felt heat sensation immediately after the bolus infusion of Mg, and had a good sleep after this therapy. However, there were not any severe side effects and significant change in HR or BP. We conclude that this therapy with magnesium once a week is safe and effective for relieving neuropathic pain.

Publication types

  • English Abstract

MeSH terms

  • Aged
  • Aged, 80 and over
  • Causalgia / drug therapy*
  • Female
  • Humans
  • Infusions, Intravenous
  • Magnesium Sulfate / administration & dosage*
  • Male
  • Middle Aged
  • Neuralgia / drug therapy*
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors


  • Receptors, N-Methyl-D-Aspartate
  • Magnesium Sulfate