Mechanical aspects of cardiac development

Prog Biophys Mol Biol. 1998;69(2-3):237-55. doi: 10.1016/s0079-6107(98)00010-8.


Heart development depends on a dynamic interaction between genetic and epigenetic factors. This paper discusses some of the biomechanical processes that help shape the heart in the embryo. First, an overview is given of some of the critical events that occur during cardiac development. Next, mechanics and modeling strategies are discussed for the morphogenetic processes of cardiac tube formation, cardiac looping, myocardial trabeculation, septation, valve formation, and muscle-fiber alignment. Finally, some considerations for future work in this area are listed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biomechanical Phenomena
  • Chick Embryo
  • Embryonic Induction*
  • Embryonic and Fetal Development*
  • Fetal Heart / anatomy & histology*
  • Fetal Heart / physiology*
  • Humans
  • Models, Cardiovascular
  • Morphogenesis