Accumulation of F-spondin in injured peripheral nerve promotes the outgrowth of sensory axons

J Neurosci. 1998 Nov 1;18(21):8875-85. doi: 10.1523/JNEUROSCI.18-21-08875.1998.


F-spondin, an extracellular matrix protein, is present in peripheral nerve during embryonic development, but its amount diminishes by birth. Axotomy of adult rat sciatic nerve, however, causes a massive upregulation of both F-spondin mRNA and protein distal to the lesion. F-spondin in the distal stump of axotomized nerve promotes neurite outgrowth of sensory neurons, as revealed by protein neutralization with F-spondin-specific antibodies. Thus, F-spondin is likely to play a role in promoting axonal regeneration after nerve injury.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Animals, Newborn
  • Antibodies / pharmacology
  • Axons / physiology*
  • Axotomy
  • Blotting, Northern
  • Cells, Cultured
  • Extracellular Matrix / metabolism
  • Gene Expression Regulation
  • Growth Substances*
  • In Situ Hybridization
  • Intercellular Signaling Peptides and Proteins
  • Nerve Regeneration*
  • Neural Cell Adhesion Molecules / immunology
  • Neural Cell Adhesion Molecules / metabolism*
  • Neurites / drug effects
  • Neurites / physiology
  • Neurons, Afferent / physiology*
  • Peptides*
  • Peripheral Nerve Injuries*
  • Peripheral Nerves / embryology
  • Peripheral Nerves / metabolism*
  • RNA, Messenger / analysis
  • Rats
  • Rats, Sprague-Dawley
  • Schwann Cells
  • Sciatic Nerve


  • Antibodies
  • Growth Substances
  • Intercellular Signaling Peptides and Proteins
  • Neural Cell Adhesion Molecules
  • Peptides
  • RNA, Messenger
  • Spon1 protein, rat