Conservation of gene order: a fingerprint of proteins that physically interact

Trends Biochem Sci. 1998 Sep;23(9):324-8. doi: 10.1016/s0968-0004(98)01274-2.


A systematic comparison of nine bacterial and archaeal genomes reveals a low level of gene-order (and operon architecture) conservation. Nevertheless, a number of gene pairs are conserved. The proteins encoded by conserved gene pairs appear to interact physically. This observation can therefore be used to predict functions of, and interactions between, prokaryotic gene products.

MeSH terms

  • Archaeal Proteins / chemistry
  • Archaeal Proteins / genetics
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / genetics
  • Evolution, Molecular
  • Genes, Archaeal*
  • Genes, Bacterial*
  • Multigene Family
  • Operon
  • Protein Folding


  • Archaeal Proteins
  • Bacterial Proteins