Notch/LIN-12 signaling: transduction by regulated protein slicing

Trends Biochem Sci. 1998 Sep;23(9):353-7. doi: 10.1016/s0968-0004(98)01263-8.


Intercellular signaling through the Notch/LIN-12 transmembrane receptors regulates growth and differentiation during animal development. Moreover, defects in the conserved Notch/LIN-12 pathway are linked to human diseases. Here, we review models for two key steps in Notch/LIN-12 signaling: ligand-mediated activation of the receptor and receptor-mediated activation of transcription. Ligand binding appears to permit proteolysis of the receptor; as a result, the receptor's intracellular domain can enter the nucleus and function as a transcriptional co-activator.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans Proteins*
  • Helminth Proteins / physiology*
  • Humans
  • Ligands
  • Membrane Proteins / physiology*
  • Models, Biological
  • Receptors, Cell Surface / physiology*
  • Receptors, Notch
  • Signal Transduction
  • Transcriptional Activation


  • Caenorhabditis elegans Proteins
  • Helminth Proteins
  • Ligands
  • Lin-12 protein, C elegans
  • Membrane Proteins
  • Receptors, Cell Surface
  • Receptors, Notch