Non-invasive papillary carcinoma of the bladder associated with carcinoma in situ

J Urol. 1976 Nov;116(5):575-80. doi: 10.1016/s0022-5347(17)58916-8.


We evaluated 129 patients with low grade, low stage transitional cell carcinoma of the bladder with a minimum followup of 5 years. In addition to the phenomena recognized as indicators of a serious clinical problem (grade greater than I, rapid recurrence, multiple tumors and lamina propria invasion) the identification of carcinoma in situ and/or atypia in normal, incidentally resected mucosa adjacent to the tumor was found to be a positive predictor for subsequent muscle invasion. Ten of 12 patients with carcinoma in situ and 9 of 25 patients with atypia were among 39 who experienced invasion.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Carcinoma in Situ / pathology*
  • Carcinoma, Transitional Cell / pathology*
  • Cell Transformation, Neoplastic / pathology
  • Cystitis / pathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Invasiveness
  • Neoplasm Recurrence, Local / pathology
  • Neoplasms, Multiple Primary / pathology
  • Prognosis
  • Risk
  • Urinary Bladder / pathology
  • Urinary Bladder Neoplasms / pathology*