Streptococcal Emm Types Associated With T-agglutination Types and the Use of Conserved Emm Gene Restriction Fragment Patterns for Subtyping Group A Streptococci

J Med Microbiol. 1998 Oct;47(10):893-8. doi: 10.1099/00222615-47-10-893.


The T-agglutination types were determined for a diverse collection of 1531 group A streptococci for which the 5' M protein gene (emm) sequences had been analysed. The majority of the T-agglutination types correlated with previously seen M/emm/T-type associations; however, several new associations were found. Analysis of a subset of this collection -- which included 1157 clinical isolates with multiply encountered emm types -- found that emm amplicon restriction profiles of isolates sharing identical T types and opacity factor phenotypes are useful for detecting groups of isolates with identical emm genes. Many emm genes of known 5' sequence display a highly conserved restriction pattern amongst clinical isolates widely separated both geographically and temporally.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Agglutination
  • Antigens, Bacterial*
  • Bacterial Outer Membrane Proteins*
  • Bacterial Proteins / genetics*
  • Base Sequence
  • Carrier Proteins*
  • Conserved Sequence*
  • Humans
  • Molecular Sequence Data
  • Peptide Hydrolases / analysis
  • Polymorphism, Restriction Fragment Length*
  • Streptococcus pyogenes / classification*
  • Streptococcus pyogenes / genetics
  • United States


  • Antigens, Bacterial
  • Bacterial Outer Membrane Proteins
  • Bacterial Proteins
  • Carrier Proteins
  • opacity factor
  • streptococcal M protein
  • Peptide Hydrolases

Associated data

  • GENBANK/AF025948
  • GENBANK/AF025949
  • GENBANK/AF035838
  • GENBANK/U74320
  • GENBANK/U92492
  • GENBANK/U94589