RNA localization: different zipcodes, same postman?

Trends Cell Biol. 1998 Oct;8(10):381-3. doi: 10.1016/s0962-8924(98)01348-8.


RNA-localization mechanisms involve specific sequences in the localized RNA and proteins that bind to these sequences and mediate the interaction with cytoskeletal elements. Until recently, it seemed as though two separate types of mechanisms were operating for mRNA localization--involving interaction with either microtubules or actin microfilaments. However, it is now clear that some of the protein components involved in mRNA localization can participate in both microtubule- and actin-dependent localization pathways. This, combined with new evidence for evolutionary conservation of some of these proteins, suggests a previously unanticipated uniformity in mRNA-localization mechanisms.

Publication types

  • Review

MeSH terms

  • Actin Cytoskeleton / physiology
  • Actins / genetics
  • Actins / physiology
  • Animals
  • Biological Transport
  • Cell Lineage
  • Drosophila melanogaster / cytology
  • Drosophila melanogaster / metabolism
  • Fibroblasts / cytology
  • Fibroblasts / metabolism
  • Insect Proteins / physiology
  • Microtubules / physiology
  • RNA, Messenger / metabolism*
  • RNA-Binding Proteins / physiology
  • Xenopus laevis / anatomy & histology


  • Actins
  • Insect Proteins
  • RNA, Messenger
  • RNA-Binding Proteins