The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594

J Physiol Paris. 1998 Jun-Aug;92(3-4):221-4. doi: 10.1016/s0928-4257(98)80014-4.


ABT-594, a nicotinic acetylcholine receptor agonist, has antinociceptive effects in rat models of acute thermal, persistent chemical, and neuropathic pain. Direct injection of ABT-594 into the nucleus raphe magnus (NRM) is antinociceptive in a thermal threshold test and destruction of serotonergic neurons in the NRM attenuates the effect of systemic ABT-594. However, lidocaine-inactivation of the NRM prevents the antinociceptive effect of systemic (-)-nicotine but not that of systemic ABT-594.

Publication types

  • Review

MeSH terms

  • Analgesics, Non-Narcotic / pharmacology*
  • Animals
  • Azetidines / pharmacology*
  • Disease Models, Animal
  • Neurons / drug effects*
  • Neurons / physiology
  • Nicotinic Agonists / pharmacology*
  • Pain / drug therapy*
  • Pain / physiopathology
  • Pyridines / pharmacology*
  • Raphe Nuclei / drug effects
  • Rats
  • Receptors, Nicotinic / physiology*


  • 5-(2-azetidinylmethoxy)-2-chloropyridine
  • Analgesics, Non-Narcotic
  • Azetidines
  • Nicotinic Agonists
  • Pyridines
  • Receptors, Nicotinic