Noninsulin-dependent diabetes mellitus as a mitochondrial genomic disease

Proc Soc Exp Biol Med. 1998 Nov;219(2):97-108. doi: 10.3181/00379727-219-44321.


The genetics of diabetes mellitus is very complex. Although the phenotypes are relatively simple vis-a-vis an abnormal glucose-insulin relationship, a number of genotypes share this phenotype. This review focuses on mutations in the mitochondrial genome that phenotype as diabetes mellitus. Studies in the human and the rat are described.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA, Mitochondrial / genetics*
  • Diabetes Mellitus, Type 2 / genetics*
  • Diabetes Mellitus, Type 2 / pathology
  • Genome, Human*
  • Humans
  • Mitochondria / genetics
  • Mutation*
  • Rats


  • DNA, Mitochondrial