Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6

Genomics. 1998 Oct 15;53(2):203-13. doi: 10.1006/geno.1998.5481.

Abstract

We report here the identification of two distinct human cDNAs, called VNN1 and VNN2, related to the recently described mouse Vanin-1 molecule involved in lymphocyte migration (M. Aurrand-Lions et al., 1996, Immunity 5: 391-405). Tissue distribution of the expression of these two human Vanin-like genes is differential. Since Vanin-1 shares significant homologies with human biotinidase (BTD), we describe here a new family of related genes including at least four members: mouse Vanin-1, VNN1, VNN2, and BTD. We have mapped the murine locus encompassing the Vanin-1 gene on mouse chromosome 10 in position A2B1. The two human Vanin-like genes are closely linked, since they were found on the same YAC clone and colocalized on human chromosome 6q23-q24 known to contain several genetic alterations linked to the progression of metastatic human cancers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amidohydrolases / genetics*
  • Amidohydrolases / metabolism*
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Biotinidase
  • Cell Adhesion Molecules / genetics*
  • Cell Adhesion Molecules / metabolism*
  • Chromosomes, Human, Pair 6*
  • Cloning, Molecular
  • GPI-Linked Proteins
  • Humans
  • Hydrolases*
  • Mice
  • Molecular Sequence Data
  • Polymerase Chain Reaction / methods
  • Protein Biosynthesis
  • Proteins / genetics*
  • Proteins / metabolism*
  • Tissue Distribution

Substances

  • Cell Adhesion Molecules
  • GPI-Linked Proteins
  • Proteins
  • Hydrolases
  • Amidohydrolases
  • pantetheinase
  • Biotinidase
  • VNN2 protein, human

Associated data

  • GENBANK/AJ132099
  • GENBANK/AJ132100