Lifespan, age changes and tumour incidence in an ageing C57BL mouse colony

Lab Anim. 1976 Oct;10(10):419-42. doi: 10.1258/002367776780956917.

Abstract

Detailed data from a colony of C57BL mice kept for research into ageing processes are given on weights of 13 organs between the ages of 6 and 30 months; pathological findings and x-ray results from animals aged 6, 24 and 30 months; age-specific tumour incidences in 24 organs in 3-month period up to 36 months of age. Results of previously published age-related studies of reproductive capacity, dental abnormalities and brain changes are summarised.

MeSH terms

  • Aging*
  • Animals
  • Body Weight
  • Bone Development
  • Female
  • Life Expectancy*
  • Male
  • Mice
  • Mice, Inbred C57BL / growth & development
  • Mice, Inbred C57BL / physiology*
  • Neoplasms / epidemiology
  • Neoplasms / veterinary*
  • Organ Size
  • Pregnancy
  • Rodent Diseases / epidemiology*