Intraoperative application of mitomycin C in the surgical treatment of pterygium

Eur J Ophthalmol. 1998 Jul-Sep;8(3):153-6.


Purpose: To investigate the effectiveness of intraoperative mitomycin C in pterygium surgery.

Methods: The effectiveness of intraoperatively administered mitomycin C and the occurrence of postoperative complications were evaluated in 17 patients with two recurrences of pterygium. The authors employed the "bare-sclera technique" and placed a sterile sponge soaked in a 0.02% mitomycin C solution intraoperatively in the episcleral space for 3 minutes. The control group (15 patients) underwent only surgical excision. Patients were followed for 21 to 30 months.

Results: The pterygium recurred in one (5.9%) of the 17 patients in group 1 and in six (40%) of the 15 controls. Statistical analysis using Fisher's exact test showed a significant (p = 0.027) reduction of recurrences of pterygium in the group treated intraoperatively with mitomycin C. No serious complications or side effects arose during the follow-up period.

Conclusions: Mitomycin C administered intraoperatively can be considered an effective treatment to improve the success rate after surgical excision.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Conjunctiva / surgery
  • Female
  • Follow-Up Studies
  • Humans
  • Intraoperative Period
  • Male
  • Middle Aged
  • Mitomycin / therapeutic use*
  • Ophthalmic Solutions
  • Ophthalmologic Surgical Procedures
  • Pterygium / drug therapy*
  • Pterygium / surgery*
  • Recurrence
  • Retrospective Studies
  • Sclera / surgery
  • Treatment Outcome


  • Ophthalmic Solutions
  • Mitomycin