Effect of supplementation with chromium picolinate on antibody titers to 5-hydroxymethyl uracil

Eur J Epidemiol. 1998 Sep;14(6):621-6. doi: 10.1023/a:1007442203258.


Recent in vitro studies have shown that chromium (III) compounds such as chromium picolinate, a popular dietary supplement among people trying to lose weight, produce chromosome damage. We monitored levels of DNA damage in a chromium picolinate supplement trial by measuring antibodies titers to an oxidized DNA base, 5-hydroxymethyl-2'-deoxyuridine (HMdU), by enzyme-linked immunosorbent assays. Ten obese volunteer women completed a 8-week course of 400 micrograms chromium picolinate per day. In either absolute titers or percent of the baseline value, there were no changes in antibody titers at 4 or 8 weeks. The titers were very stable within individuals and those of one individual rarely crossed over others, which was reflected in an intraclass correlation coefficient of 0.99 (95% confidence interval: 0.96-1.00). There were no effects on glucose and lipid metabolism in this period. The results of this trial suggest that chromium (III) picolinate in a dose typically used for nutrient supplementation dose not increase oxidative DNA damage, as measured by anti-HMdU antibody levels.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase II

MeSH terms

  • Analysis of Variance
  • Antibody Formation / drug effects
  • Confidence Intervals
  • DNA Damage / drug effects
  • Dietary Supplements*
  • Female
  • Humans
  • Immunoglobulin M / analysis
  • Immunoglobulin M / drug effects*
  • Iron Chelating Agents / administration & dosage*
  • Middle Aged
  • Obesity / drug therapy*
  • Obesity / immunology*
  • Pentoxyl / analogs & derivatives*
  • Pentoxyl / immunology
  • Picolinic Acids / administration & dosage*
  • Picolinic Acids / urine
  • Prospective Studies


  • Immunoglobulin M
  • Iron Chelating Agents
  • Picolinic Acids
  • 5-hydroxymethyluracil
  • Pentoxyl
  • picolinic acid