Serum concentrations of organochlorine compounds and endometrial cancer risk (United States)

Cancer Causes Control. 1998 Aug;9(4):417-24. doi: 10.1023/a:1008823802393.

Abstract

Objectives: Endogenous and exogenous estrogens are important in the development of endometrial cancer. Several organochlorine compounds, such as o,p'-DDT, have estrogenic properties. The objective of this case-control analysis was to examine serum concentrations of organochlorine compounds and risk of endometrial cancer.

Methods: Analyses were based on a sample of 90 endometrial cancer cases and 90 individually matched community controls from a multicenter case-control study in five geographic regions of the United States. Information on potential confounders, including menstrual and reproductive factors, cigarette smoking, diet, and weight, was obtained by interview.

Results: The adjusted relative risk of endometrial cancer in the highest quartile of exposure compared with women in the lowest quartile was 0.7 (95 percent confidence interval [CI] = 0.2-2.0) for p,p'-DDE, and 0.9 for total polychlorinated biphenyls (PCBs) (CI = 0.4-2.5).

Conclusions: These findings do not support the hypothesis that organochlorine compounds are linked to the development of endometrial cancer.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Carcinoma / blood*
  • Carcinoma / epidemiology
  • Case-Control Studies
  • Confidence Intervals
  • Endometrial Neoplasms / blood*
  • Endometrial Neoplasms / epidemiology
  • Female
  • Humans
  • Hydrocarbons, Chlorinated*
  • Incidence
  • Insecticides / blood*
  • Logistic Models
  • Middle Aged
  • Risk Assessment
  • Risk Factors
  • United States / epidemiology

Substances

  • Hydrocarbons, Chlorinated
  • Insecticides