The Grb7 family of signalling proteins

Cell Signal. 1998 Oct;10(9):613-8. doi: 10.1016/s0898-6568(98)00022-9.


The Grb7 family is a rapidly emerging group of Src homology (SH)2 domain-containing signalling proteins that currently contains three members, Grb7, 10 and 14. These proteins possess a conserved multidomain structure, including a central region exhibiting significant homology to the Caenorhabditis elegans protein Mig10. Differences in tissue expression and SH2 binding selectivity suggest that these adaptor proteins function in a tissue-specific manner to link specific receptor tyrosine kinases (RTKs) and other tyrosine phosphorylated proteins to as yet uncharacterised downstream effectors. Interestingly, Grb7 proteins exhibit differential expression amongst a variety of human cancers and cancer cell lines. Consequently, these proteins not only are likely to perform a fundamental signalling role, but may also modulate RTK signalling in cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Caenorhabditis elegans Proteins*
  • GRB7 Adaptor Protein
  • Gene Expression
  • Helminth Proteins / metabolism
  • Humans
  • Molecular Sequence Data
  • Neoplasms / metabolism
  • Phosphorylation
  • Proteins / chemistry
  • Proteins / genetics
  • Proteins / metabolism*
  • Receptor Protein-Tyrosine Kinases / metabolism
  • Signal Transduction / physiology*
  • src Homology Domains


  • Caenorhabditis elegans Proteins
  • GRB7 protein, human
  • Helminth Proteins
  • Mig-10 protein, C elegans
  • Proteins
  • GRB7 Adaptor Protein
  • Receptor Protein-Tyrosine Kinases