Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family

Cell Signal. 1998 Oct;10(9):619-28. doi: 10.1016/s0898-6568(98)00023-0.


The receptors for the I1-3/IL-5/GM-CSF cytokine family are composed of a heterodimeric complex of a cytokine-specific alpha chain and a common beta chain (betac). Binding of IL-3/IL-5/GM-CSF to their respective receptors rapidly induces activation of multiple intracellular signalling pathways, including the Ras-Raf-ERK, the JAK/STAT, the phosphatidylinositol 3-kinase PKB, and the JNK/SAPK and p38 signalling pathways. This review focuses on recent advancements in understanding how these different signalling pathways are activated by IL-3/IL-5/GM-CSF receptors, and how the individual pathways contribute to the pleiotropic effects of IL-3/IL-5/GM-CSF on their target cells, including proliferation, differentiation, survival, and effector functions.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism
  • Cell Differentiation / physiology
  • Cell Division / physiology
  • Cell Survival / physiology
  • DNA-Binding Proteins / metabolism
  • Granulocyte-Macrophage Colony-Stimulating Factor / metabolism
  • Humans
  • Interleukin-3 / metabolism
  • Interleukin-5 / metabolism*
  • Milk Proteins*
  • Phosphatidylinositol 3-Kinases / metabolism
  • Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / metabolism*
  • Receptors, Interleukin-3 / metabolism*
  • STAT5 Transcription Factor
  • Signal Transduction / physiology
  • Trans-Activators / metabolism


  • DNA-Binding Proteins
  • Interleukin-3
  • Interleukin-5
  • Milk Proteins
  • Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
  • Receptors, Interleukin-3
  • STAT5 Transcription Factor
  • Trans-Activators
  • Granulocyte-Macrophage Colony-Stimulating Factor
  • Phosphatidylinositol 3-Kinases
  • Calcium-Calmodulin-Dependent Protein Kinases