Chymase gene locus is not associated with myocardial infarction and is not linked to heart size or blood pressure

Am J Cardiol. 1998 Oct 15;82(8):979-81. doi: 10.1016/s0002-9149(98)00518-9.


The chymase gene is said to be important for the generation of angiotensin II in the heart and therefore is a candidate gene for heart disease. However, we were unable to find an association between allelic variants of the chymase gene and acute myocardial infarction or linkage between the chymase gene locus and heart size.

Publication types

  • Research Support, Non-U.S. Gov't
  • Twin Study

MeSH terms

  • Adult
  • Base Sequence
  • Blood Pressure / genetics*
  • Cardiomegaly / genetics*
  • Chymases
  • Female
  • Genetic Linkage
  • Genotype
  • Humans
  • Male
  • Microsatellite Repeats
  • Molecular Sequence Data
  • Myocardial Infarction / genetics*
  • Polymorphism, Genetic
  • Reference Values
  • Serine Endopeptidases / genetics*
  • Twins / genetics*


  • Serine Endopeptidases
  • Chymases