The nuclear receptor PPARgamma - bigger than fat

Curr Opin Genet Dev. 1998 Oct;8(5):576-81. doi: 10.1016/s0959-437x(98)80014-2.

Abstract

Work reported over the past year has provided insights into the mechanisms whereby ligand activation of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) regulates systemic glucose and lipid homeostasis. PPARgamma has also been implicated recently in the biology of monocytes and in cell-cycle regulation and cancer. Polyunsaturated fatty acids and eicosanoids bind and activate PPARgamma, suggesting that these lipids may serve as hormonal regulators of a variety of biological processes.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • DNA-Binding Proteins / metabolism*
  • Fatty Acids, Unsaturated / metabolism
  • Glucose / metabolism
  • Homeostasis
  • Humans
  • Lipid Metabolism
  • Monocytes / physiology
  • Neoplasms / physiopathology
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Transcription Factors / metabolism*

Substances

  • DNA-Binding Proteins
  • Fatty Acids, Unsaturated
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors
  • Glucose