Regulation of glucose utilization in yeast

Curr Opin Genet Dev. 1998 Oct;8(5):560-4. doi: 10.1016/s0959-437x(98)80011-7.


Our understanding of the regulatory mechanisms controlling the glucose response in yeast has advanced in the past year. Two transporter-like proteins have been shown to function as glucose sensors in a pathway for glucose induction of transporter genes. Our understanding of the glucose repression mechanism has been augmented by studies of the Snf1 protein kinase, the Mig1 repressor, and the role of Snf1 in inhibiting Mig1 and regulating activators. DNA microarrays have been used to assess glucose-regulated gene expression.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • DNA, Fungal / chemistry
  • DNA, Fungal / genetics
  • DNA, Fungal / metabolism
  • DNA-Binding Proteins / metabolism
  • Fungal Proteins / metabolism
  • Gene Expression Regulation, Fungal*
  • Glucose / metabolism*
  • Models, Biological
  • Protein-Serine-Threonine Kinases / metabolism
  • Repressor Proteins / metabolism
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / physiology*
  • Saccharomyces cerevisiae Proteins
  • Trans-Activators / metabolism


  • DNA, Fungal
  • DNA-Binding Proteins
  • Fungal Proteins
  • MIG1 protein, S cerevisiae
  • Repressor Proteins
  • Saccharomyces cerevisiae Proteins
  • Trans-Activators
  • SNF1-related protein kinases
  • Protein-Serine-Threonine Kinases
  • Glucose