Genetic dissection of glucocorticoid receptor function in mice

Curr Opin Genet Dev. 1998 Oct;8(5):532-8. doi: 10.1016/s0959-437x(98)80007-5.

Abstract

Upon hormone binding, the activated glucocorticoid receptor (GR) functions as a transcription factor via different modes of action to control gene expression. Recent gene-targeting studies in mice provide new insight into the role of GR in vivo and are helping decipher the molecular mechanisms underlying its actions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation*
  • Homeostasis
  • Mice
  • Models, Biological
  • Receptors, Glucocorticoid / chemistry
  • Receptors, Glucocorticoid / genetics*
  • Receptors, Glucocorticoid / metabolism*
  • Signal Transduction
  • Stress, Physiological
  • Transcription Factors / metabolism*
  • Transcription, Genetic

Substances

  • Receptors, Glucocorticoid
  • Transcription Factors