Genetic dissection of glucocorticoid receptor function in mice

F Tronche; C Kellendonk; H M Reichardt; G Schütz

doi:10.1016/s0959-437x(98)80007-5

Genetic dissection of glucocorticoid receptor function in mice

Curr Opin Genet Dev. 1998 Oct;8(5):532-8. doi: 10.1016/s0959-437x(98)80007-5.

Authors

F Tronche¹, C Kellendonk, H M Reichardt, G Schütz

Affiliation

¹ Molecular Biology of the Cell I, Deutsches Krebsforschungzentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Federal Republic of Germany.

PMID: 9794823
DOI: 10.1016/s0959-437x(98)80007-5

Abstract

Upon hormone binding, the activated glucocorticoid receptor (GR) functions as a transcription factor via different modes of action to control gene expression. Recent gene-targeting studies in mice provide new insight into the role of GR in vivo and are helping decipher the molecular mechanisms underlying its actions.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Gene Expression Regulation*
Homeostasis
Mice
Models, Biological
Receptors, Glucocorticoid / chemistry
Receptors, Glucocorticoid / genetics*
Receptors, Glucocorticoid / metabolism*
Signal Transduction
Stress, Physiological
Transcription Factors / metabolism*
Transcription, Genetic

Substances

Receptors, Glucocorticoid
Transcription Factors