Regulatory targets in the RNA polymerase II holoenzyme

Curr Opin Genet Dev. 1998 Oct;8(5):565-70. doi: 10.1016/s0959-437x(98)80012-9.

Abstract

The RNA polymerase II holoenzyme is the form of polymerase recruited to promoters for protein-coding genes. Several targets of mammalian activators, previously called coactivators, turn out to be subunits of the holoenzyme which activators use to recruit and regulate the holoenzyme. Several of these newly identified holoenzyme components have been implicated in human disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Disease
  • Gene Expression Regulation*
  • Holoenzymes / metabolism
  • Humans
  • Models, Genetic
  • Promoter Regions, Genetic*
  • RNA Polymerase II / metabolism*
  • Transcription Factors / metabolism

Substances

  • Holoenzymes
  • Transcription Factors
  • RNA Polymerase II