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Review
. 1998 Oct;10(5):559-63.
doi: 10.1016/s0952-7915(98)80224-0.

TRAIL: A Molecule With Multiple Receptors and Control Mechanisms

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Review

TRAIL: A Molecule With Multiple Receptors and Control Mechanisms

T S Griffith et al. Curr Opin Immunol. .

Abstract

Apoptosis research is benefiting from bioinformatic approaches to identify new components of the cell death machinery and novel cell death inducers/receptors. Over the past year, knowledge of the system involving TNF-related apoptosis-inducing ligand (TRAIL) and its receptors has increased via genomic database analysis to include four distinct receptors that interact with a single ligand. Currently, these molecules are of major interest due to their potential roles and application in cancer therapy.

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