Effects of dianabol and high-intensity sprint training on body composition of rats

Med Sci Sports. Fall 1976;8(3):191-5. doi: 10.1249/00005768-197600830-00011.

Abstract

The effects on body composition and organ weights of anabolic steroid administration and of high-intensity sprint running, separately and in combination, were studied in young adult male rats. Dianabol (methandrostenolone) 1 mg/day for 8 weeks had no significant effects on muscle weight or lean body mass in either the trained or the sedentary animals. The program of sprint training resulted in a lower body weight, a lesser percentage of body fat (Runners, 8.5%, vs. sedentary, 13.5% P less than 0.01) and a greater relative lean body mass (runners, 91.5% vs. sedentry, 86.5%, P less than 0.01). We conclude from these results that (a) normal androgen levels in young, healthy male animals are sufficiently high so that the addition of a large dose of anabolic steroid does not result in stimulation of additional muscle growth, and (b) the changes in body composition induced by high-intensity, short-duration sprint training are qualitatively similar to those seen with endurance exercise training.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenal Glands / analysis
  • Animals
  • Body Composition* / drug effects
  • Heart / anatomy & histology
  • Kidney / anatomy & histology
  • Liver / anatomy & histology
  • Male
  • Methandrostenolone / pharmacology*
  • Muscles / anatomy & histology
  • Organ Size
  • Placebos
  • Rats
  • Running*
  • Testis / anatomy & histology

Substances

  • Placebos
  • Methandrostenolone