Comment on the cylindrical capacitor electrospray interface

Anal Chem. 1998 Oct 15;70(20):4453-5. doi: 10.1021/ac980169j.

Abstract

Wang and Hackett have recently proposed (Anal. Chem. 1998, 70, 205-212) a new electrospray interface described as a "concentric cylindrical capacitor". Excellent spectra were obtained, especially in the negative ion mode, with lipid A, a 15-mer oligonucleotide, and a series of proteins. We find that similar results can be obtained merely by ensuring a direct electrical contact between the analyte inside a fused-silica capillary and the high-voltage supply. No capacitor effect need be invoked.

Publication types

  • Comparative Study
  • Letter

MeSH terms

  • Lipid A / chemistry
  • Mass Spectrometry / instrumentation*
  • Oligonucleotides / chemistry
  • Proteins / chemistry
  • Silicon Dioxide

Substances

  • Lipid A
  • Oligonucleotides
  • Proteins
  • Silicon Dioxide