In vitro efficacy and fungicidal activity of voriconazole against Aspergillus and Fusarium species

Eur J Clin Microbiol Infect Dis. 1998 Aug;17(8):573-5. doi: 10.1007/BF01708622.

Abstract

Twenty-nine Aspergillus isolates and 25 Fusarium isolates underwent in vitro antifungal susceptibility testing by a broth macrodilution procedure adapted from the National Committee for Clinical Laboratory Standards guidelines. The MIC50s of both voriconazole and amphotericin B were 0.5 microg/ml and 1 microg/ml against species of Aspergillus and Fusarium, respectively, while the MIC90s of both agents were 1 and 2 microg/ml. Voriconazole was more active in vitro than amphotericin B: the geometric mean MICs of voriconazole and amphotericin B against Aspergillus spp. were 0.36 microg/ml and 0.64 microg/ml, respectively. Voriconazole also demonstrated fungicidal activity against Aspergillus spp., with 86% (24/29) of isolates exhibiting minimum lethal concentrations of < or = 4 microg/ml.

MeSH terms

  • Antifungal Agents / pharmacology*
  • Aspergillus / drug effects*
  • Drug Evaluation, Preclinical
  • Fusarium / drug effects*
  • Pyrimidines / pharmacology*
  • Triazoles / pharmacology*
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Voriconazole