Systemic mastocytosis presenting as profound cardiovascular collapse during anaesthesia

Anaesthesia. 1998 Aug;53(8):804-7. doi: 10.1046/j.1365-2044.1998.00536.x.


Mastocytosis is a rare disorder with serious anaesthetic implications. Anaesthetic management is hazardous since trauma, stress, extremes of temperature and drugs may precipitate intra-operative mast cell degranulation. Release of histamine and other mast cell mediators can lead to profound cardiovascular collapse and even death. We present a case report of a patient with mastocytosis who suffered cardiac arrest during anaesthesia. Anaphylactoid/anaphylactic shock may be delayed and lack supporting signs of histamine release such as cutaneous flushing and bronchospasm.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anesthesia, General / adverse effects*
  • Fatal Outcome
  • Heart Arrest / etiology*
  • Humans
  • Intraoperative Complications*
  • Male
  • Mastocytosis / complications*