Abstract
The nm23 monoclonal antibody directed to specific antigen was applied for investigation of 29 benign naevi, 59 melanomas of different Clark level and locations, 4 lymph node and 28 organ metastases, using quantitative immunohistochemistry. The reduced expression of nm23 protein was associated with the tumor progression. A statistically significant difference (p = 0.0014) was found in nm23 protein expression between naevi and malignant melanomas. Additionally, a reduced protein level in metastases was found. A strong correlation was found between nm23 expression and survival of patients as well as the presence of metastasis (p = 0.0003).
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Biomarkers, Tumor / metabolism*
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Disease Progression
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Female
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Humans
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Immunohistochemistry
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Male
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Melanoma / metabolism*
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Melanoma / pathology
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Middle Aged
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Monomeric GTP-Binding Proteins*
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NM23 Nucleoside Diphosphate Kinases
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Nevus / metabolism
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Nevus / pathology
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Nucleoside-Diphosphate Kinase*
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Prognosis
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Skin Neoplasms / metabolism*
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Skin Neoplasms / pathology
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Transcription Factors / metabolism*
Substances
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Biomarkers, Tumor
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NM23 Nucleoside Diphosphate Kinases
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Transcription Factors
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NME1 protein, human
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Nucleoside-Diphosphate Kinase
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Monomeric GTP-Binding Proteins