Risk factors associated with nasopharyngeal carcinoma

N Engl J Med. 1976 Nov 11;295(20):1101-6. doi: 10.1056/NEJM197611112952003.

Abstract

We performed a case-control study of nasopharyngeal squamous-cell carcinoma to identify risk factors associated with the disease. Interviews with 156 patients and 267 controls revealed that increased risk was significantly associated with a prior history of ear, nose or throat disease (relative risk = 1.8, P = 0.006) and occupational exposure to fumes (relative risk = 2.0, P = 0.006), smoke (relative risk = 3.0, P = 0.008) and chemicals (relative risk = 2.4, P = 0.006). Among Chinese, other Asians and Mexican-Americans, increased risk was also associated with foreign birthplace (relative risk = 2.1, P = 0.04), probably reflecting childhood exposure to carcinogens in inhaled smoke. In Chinese patients the risk associated with foreign birthplace and occupational exposure increased among those with HLA-A2 and less than two antigens at the B locus, suggesting a genetic variation in susceptibility.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Asia / ethnology
  • Asian Continental Ancestry Group
  • California
  • Carcinoma, Squamous Cell / epidemiology*
  • Carcinoma, Squamous Cell / genetics
  • China / ethnology
  • Environmental Exposure
  • Environmental Pollutants
  • Ethnic Groups
  • European Continental Ancestry Group
  • Female
  • HLA Antigens
  • Humans
  • Male
  • Mexico / ethnology
  • Middle Aged
  • Nasopharyngeal Neoplasms / epidemiology*
  • Nasopharyngeal Neoplasms / genetics
  • Risk
  • Smoking / complications

Substances

  • Environmental Pollutants
  • HLA Antigens