Significant linkage between bipolar affective disorder and chromosome 12q24

Psychiatr Genet. Autumn 1998;8(3):131-40. doi: 10.1097/00041444-199800830-00002.

Abstract

Chromosome 12q23-q24.1 has been implied by a few linkage and association studies as a candidate region for affective disorder. The present study investigated for linkage between bipolar affective disorder and 16 microsatellite markers covering chromosome 12q22-q24 in two Danish families. Assuming homogeneity and a dominant mode of inheritance, a significant two-point lod score of 3.37 was found at D12S1639, when only bipolar patients were considered as affected. The lod score was supported by neighbouring markers. The empirical P-value for this lod score was 0.00002. Non-parametric analyses using SimIBD supported this finding, with P-values of 0.00003 and 0.005 at D12S1639. An overlapping segment of chromosome 12q24 was shared among all except one of the bipolar patients, with apparently different haplotypes in each family.

MeSH terms

  • Bipolar Disorder / epidemiology
  • Bipolar Disorder / genetics*
  • Chromosomes, Human, Pair 12 / genetics*
  • Consanguinity
  • Darier Disease / genetics
  • Denmark / epidemiology
  • Female
  • Genes, Dominant
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Haplotypes / genetics
  • Humans
  • Lod Score
  • Male
  • Pedigree
  • Phospholipases A / genetics

Substances

  • Genetic Markers
  • Phospholipases A