A rapid HPLC assay for voriconazole in human plasma

J Pharm Biomed Anal. 1998 Sep;17(8):1449-53. doi: 10.1016/s0731-7085(98)00004-1.

Abstract

This report describes a simple, rapid and reproducible method with a calibration range of 0.2-10 micrograms ml-1 voriconazole in human plasma which is more appropriate for routine clinical use than the authors previously published method. The method utilises protein precipitation with acetonitrile as the only sample preparation involved prior to reverse phase HPLC. No internal standard was required.

MeSH terms

  • Antifungal Agents / blood*
  • Chromatography, High Pressure Liquid / methods*
  • Humans
  • Pyrimidines / blood*
  • Reproducibility of Results
  • Triazoles / blood*
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Voriconazole