Parkinson's disease selectively impairs preattentive auditory processing: an MEG study

Neuroreport. 1998 Sep 14;9(13):2949-52. doi: 10.1097/00001756-199809140-00006.


Auditory stimuli elicit auditory evoked magnetic fields (AEFs) called P50m and N100m, which index preconscious auditory processing in human. We investigated with a whole-head magnetometer whether Parkinson's disease (PD) impairs parallel preattentive auditory processing between the hemispheres. Stimulus blocks consisting of standard (80%) and deviant (20%) tones were monaurally presented in a passive condition to 11 PD patients with unilateral motor symptoms and to 11 age-matched healthy controls. The constant interstimulus intervals (ISIs) were 0.5 s and 2.5 s in separate blocks. The interhemispheric latency differences of the P50m and N100m were significantly lengthened in PD patients in the left-ear condition. This might be caused by the basal ganglia dysfunction in PD together with the simultaneous age-related neural degeneration predominant in the left auditory cortex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustic Stimulation
  • Analysis of Variance
  • Auditory Pathways / physiology
  • Auditory Perception / physiology*
  • Electrooculography
  • Evoked Potentials, Auditory / physiology
  • Functional Laterality
  • Humans
  • Magnetoencephalography*
  • Middle Aged
  • Parkinson Disease / physiopathology*
  • Time Factors