Fluvoxamine-induced erectile dysfunction responding to sildenafil

J Sex Marital Ther. 1998 Oct-Dec;24(4):313-7. doi: 10.1080/00926239808403967.


Sildenafil, a peripherally acting inhibitor of cyclic guanosine monophosphate((cGMP), has been reported highly effective in treating erectile dysfunction of various etiology. Erectile dysfunction is a common sexual side effect of various antidepressants. Various agents have been used in the treatment of antidepressant-induced erectile dysfunction; however, there are no reports on the use of sildenafil for this indication. This case report describes the successful use of sildenafil in fluvoxamine-induced erectile dysfunction. A possible mechanism of action of sildenafil in this type of erectile dysfunction is discussed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Enzyme Inhibitors / therapeutic use*
  • Fluvoxamine / adverse effects*
  • Humans
  • Male
  • Penile Erection / drug effects*
  • Piperazines / pharmacology*
  • Piperazines / therapeutic use*
  • Purines
  • Selective Serotonin Reuptake Inhibitors / adverse effects*
  • Sexual Dysfunction, Physiological / chemically induced*
  • Sexual Dysfunction, Physiological / drug therapy*
  • Sildenafil Citrate
  • Sulfones


  • Enzyme Inhibitors
  • Piperazines
  • Purines
  • Serotonin Uptake Inhibitors
  • Sulfones
  • Sildenafil Citrate
  • Fluvoxamine