Predictors of lymphoma development in primary Sjögren's syndrome

Semin Arthritis Rheum. 1998 Oct;28(2):80-7. doi: 10.1016/s0049-0172(98)80040-1.


Objective: To determine the clinical and laboratory predictors of lymphoma development in primary Sjögren's syndrome (pSS).

Methods: Seventy-two patients with pSS were studied. Demographic data, clinical features, serum gamma-globulin levels, autoantibodies, and HLA status were reviewed. For statistical analysis, Mann-Whitney U-test, Fisher's exact test, logistic regression analysis, Kaplan-Meier method, and log-rank tests were applied.

Results: Five patients developed a distinct non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue (MALT). A history of swollen salivary glands, lymphadenopathy, and leg ulcers predicted lymphoma development.

Conclusion: Patients with pSS are at increased risk of lymphoma development, and those who have the above risk factors must be carefully observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age of Onset
  • Aged
  • Cohort Studies
  • Comorbidity
  • Female
  • Humans
  • Lymphoma, B-Cell, Marginal Zone / mortality*
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Predictive Value of Tests
  • Prevalence
  • Retrospective Studies
  • Sjogren's Syndrome / mortality*
  • Survival Analysis