Aiolos Regulates B Cell Activation and Maturation to Effector State

Immunity. 1998 Oct;9(4):543-53. doi: 10.1016/s1074-7613(00)80637-8.

Abstract

Aiolos encodes a zinc finger DNA-binding protein that is highly expressed in mature B cells and is homologous to Ikaros. In the periphery of mice homozygous for an Aiolos-null mutation, B cells exhibit an activated cell surface phenotype and undergo augmented antigen receptor (BCR)-mediated in vitro proliferative responses, even at limiting amounts of stimulant. In vivo, T cell-dependent B cell responses, including the formation of germinal centers and elevated serum IgG and IgE, are detected in Aiolos-deficient mice in the absence of immunization. Auto-antibodies and development of B cell lymphomas are frequently seen among aging Aiolos mutants. In sharp contrast to conventional B cells, B cells of the peritoneum, of the marginal zone, and the recirculating bone marrow population are greatly reduced.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Autoantibodies / blood
  • B-Lymphocytes / cytology
  • B-Lymphocytes / immunology*
  • Base Sequence
  • Cell Differentiation
  • Cytokines / biosynthesis
  • DNA Primers / genetics
  • DNA-Binding Proteins*
  • Hematopoietic Stem Cells / cytology
  • Hematopoietic Stem Cells / immunology
  • Ikaros Transcription Factor
  • Immunoglobulins / blood
  • In Vitro Techniques
  • Lymphocyte Activation
  • Lymphoma, B-Cell / etiology
  • Lymphoma, B-Cell / pathology
  • Macromolecular Substances
  • Mice
  • Mice, Knockout
  • Phenotype
  • T-Lymphocytes / immunology
  • Trans-Activators / chemistry
  • Trans-Activators / genetics
  • Trans-Activators / immunology*
  • Transcription Factors / chemistry
  • Transcription Factors / immunology
  • Zinc Fingers / genetics
  • Zinc Fingers / immunology

Substances

  • Autoantibodies
  • Cytokines
  • DNA Primers
  • DNA-Binding Proteins
  • Ikzf3 protein, mouse
  • Immunoglobulins
  • Macromolecular Substances
  • Trans-Activators
  • Transcription Factors
  • Zfpn1a1 protein, mouse
  • Ikaros Transcription Factor