Identification of mammaglobin B, a novel member of the uteroglobin gene family

Genomics. 1998 Nov 15;54(1):70-8. doi: 10.1006/geno.1998.5539.


In this report, we have identified, sequenced, and characterized the expression pattern of a novel human gene, mammaglobin B. Mammaglobin B (MGB2) is highly homologous to mammaglobin (MGB1), a previously characterized human gene whose expression is limited to the mammary epithelium and frequently up-regulated in human breast cancer cells. Based upon amino acid sequence similarities, both mammaglobin and mammaglobin B may be considered members of a larger, mammalian multigene family that includes rabbit uteroglobin, human Clara Cell 10-kDa protein (CC10), and the multimeric rat prostatein protein. Together with the human CC10 gene, mammaglobin and mammaglobin B are closely linked on human chromosome 11q13. However, despite their primary sequence similarity and close chromosomal proximity, the expression of mammaglobin and mammaglobin B is nonconcordant in both nonmalignant and neoplastic tissue.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Northern
  • Breast / metabolism
  • Breast Neoplasms / metabolism
  • Chromosomes, Human, Pair 11 / genetics
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence
  • Mammaglobin A
  • Mammaglobin B
  • Molecular Sequence Data
  • Myelin Proteins
  • Neoplasm Proteins / chemistry
  • Neoplasm Proteins / genetics*
  • Neoplasm Proteins / metabolism
  • Polymerase Chain Reaction
  • Proteins / genetics
  • Proteolipids
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Salivary Glands / metabolism
  • Secretoglobins
  • Uterine Neoplasms / metabolism
  • Uteroglobin / chemistry
  • Uteroglobin / genetics*
  • Uteroglobin / metabolism
  • Uterus / metabolism


  • Mammaglobin A
  • Mammaglobin B
  • Myelin Proteins
  • Neoplasm Proteins
  • Proteins
  • Proteolipids
  • RNA, Messenger
  • SCGB1A1 protein, human
  • SCGB2A1 protein, human
  • SCGB2A2 protein, human
  • Scgb1a1 protein, rat
  • Secretoglobins
  • Uteroglobin

Associated data

  • GENBANK/AF071219