The nitric oxide system and cortisol-induced hypertension in humans

Clin Exp Pharmacol Physiol. 1998 Nov;25(11):945-6. doi: 10.1111/j.1440-1681.1998.tb02349.x.

Abstract

1. The aim of the present study was to assess the role of the nitric oxide (NO) system in cortisol-induced hypertension in humans. 2. Plasma and urinary nitrate/nitrite concentrations and plasma concentrations of arginine and symmetric (SDMA) and asymmetric (ADMA) dimethyl arginine were measured in six subjects on a restricted nitrate diet who were treated with 80 mg/day cortisol and in subjects on an unrestricted nitrate diet who were treated with cortisol (80 mg/day, n = 6, or 200 mg/day, n = 10) for 5 days. 3. Cortisol significantly increased systolic and mean arterial pressure. Significant reductions in plasma nitrate/nitrite concentrations were observed in subjects on a restricted nitrate diet on days 3, 4 and 5 of cortisol treatment (to 11 +/- 1, 10 +/- 1, 11 +/- 1 pmol/L, respectively) compared with pretreatment (16 +/- 1 pmol/L; P < 0.01). There were no significant changes in plasma arginine, ADMA or SDMA concentrations. 4. Cortisol treatment significantly increased blood pressure and reduced plasma nitrate/nitrite concentrations. Reductions in plasma nitrate concentrations are not explained by changes in substrate availability or in endogenous nitric oxide synthase inhibitors. These data support a role for the NO system in cortisol-induced hypertension in humans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arginine / analogs & derivatives
  • Arginine / blood
  • Arginine / urine
  • Humans
  • Hydrocortisone
  • Hypertension / blood
  • Hypertension / chemically induced
  • Hypertension / metabolism*
  • Male
  • Nitrates / blood
  • Nitrates / urine
  • Nitric Oxide / metabolism
  • Nitric Oxide / physiology*
  • Nitric Oxide Synthase / metabolism
  • Nitrites / blood
  • Nitrites / urine

Substances

  • Nitrates
  • Nitrites
  • Nitric Oxide
  • N,N-dimethylarginine
  • Arginine
  • Nitric Oxide Synthase
  • Hydrocortisone